Training session about DDpred.org principles. Applications and hands-on will be held in Hotel Campanile Part-Dieu, Lyon, France.
Objectives
- Learn the mechanisms of drugs metabolic interactions
- Know how to predict their impact and variance factors with DDpred.org
- Know how to compute a dosage adaptation
- Understand the limits and constraints of this technique
Schedule Outline
- Introduction
- Concepts and principles of quantitative prediction of IAM
- Cytochromes mediated IAM. Presentation of the DDI module of DDpred.org
- Impact of CYP polymorphism on exposure. Presentation of the Polymorphism module of DDpred.org
- Impact of polymorphism on IAM. Presentation of the DDI+Polymorphism module of DDpred.org
- Impact of Cirrhosis
- Impact of Cirrhosis on exposure. Presentation of the Cirrhosis module of DDpred.org
- Impact of Cirrhosis on IAM. Presentation of the DDI+Cirrhosis module of DDpred.org
- Clinical cases analysis
- Closing words