INNOVATIVE
DDPred is a new tool based on recent methodological developments
DDPred is a new tool based on recent methodological developments
No information is stored on our server, the user keeps all of the data
The database and the functionalities are updated frequently
Extensive external validation testing ensures the reliability of each functionnality
Advice and tutorials help users make the most of DDPred
DDPred addresses the impact of CYP polymorphism, cirrhosis and immaturity
Results are available in seconds
Very limited data are needed for a run
If you are developing a new chemical entity (NCE) and want to determine the major P450 cytochrome-mediated pharmacokinetic interactions with your NCE, DDPred can calculate the AUC ratios for all combinations of the NCE using the wide range of compounds in our internal database.
DDPred Extended allows the user to calculate the impact of the following on drugs that are metabolized by CYPs: CYP genetic polymorphisms, drug interactions combined with genetic polymorphisms, cirrhosis, drug interactions in the presence of cirrhosis, drug clearance and drug interactions in the paediatric population.
DDPred uses steady-state physiologically-based pharmacokinetic models that are based exclusively on clinical data. This avoids the issues associated with in vitro – in vivo extrapolation and scaling.